The meme is to bold the ones you've read....
The Lord of the Rings, J.R.R. Tolkien
The Foundation Trilogy, Isaac Asimov
Dune, Frank Herbert
Stranger in a Strange Land, Robert A. Heinlein
A Wizard of Earthsea, Ursula K. Le Guin
Neuromancer, William Gibson
Childhood's End, Arthur C. Clarke
Do Androids Dream of Electric Sheep?, Philip K. Dick
The Mists of Avalon, Marion Zimmer Bradley
Fahrenheit 451, Ray Bradbury
The Book of the New Sun, Gene Wolfe
A Canticle for Leibowitz, Walter M. Miller, Jr.
The Caves of Steel, Isaac Asimov
Children of the Atom, Wilmar Shiras
Cities in Flight, James Blish
The Colour of Magic, Terry Pratchett
Dangerous Visions, edited by Harlan Ellison
Deathbird Stories, Harlan Ellison
The Demolished Man, Alfred Bester
Dhalgren, Samuel R. Delany
Dragonflight, Anne McCaffrey
Ender's Game, Orson Scott Card
The First Chronicles of Thomas Covenant the Unbeliever, Stephen R. Donaldson
The Forever War, Joe Haldeman
Gateway, Frederik Pohl
Harry Potter and the Philosopher's Stone, J.K. Rowling
The Hitchhiker's Guide to the Galaxy, Douglas Adams
I Am Legend, Richard Matheson
Interview with the Vampire, Anne Rice
The Left Hand of Darkness, Ursula K. Le Guin
Little, Big, John Crowley
Lord of Light, Roger Zelazny
The Man in the High Castle, Philip K. Dick
Mission of Gravity, Hal Clement
More Than Human, Theodore Sturgeon
The Rediscovery of Man, Cordwainer Smith
On the Beach, Nevil Shute
Rendezvous with Rama, Arthur C. Clarke
Ringworld, Larry Niven
Rogue Moon, Algis Budrys
The Silmarillion, J.R.R. Tolkien
Slaughterhouse-5, Kurt Vonnegut
Snow Crash, Neal Stephenson
Stand on Zanzibar, John Brunner
The Stars My Destination, Alfred Bester
Starship Troopers, Robert A. Heinlein
Stormbringer, Michael Moorcock
The Sword of Shannara, Terry Brooks (like P.Z. Myers, I started this one and found it unreadable)
Timescape, Gregory Benford
To Your Scattered Bodies Go, Philip Jose Farmer
Some missing: John Brunner
The Shockwave Rider, Heinlein's
The Moon is a Harsh Mistress, Harry Harrison's Stainless Steel Rat books, Stanislaw Lem's
The Cyberiad or
Solaris, Rudy Rucker's work, Robert Shea and Robert Anton Wilson's
Illuminatus!, D.F. Jones'
Colossus, Pierre Boulle's
Planet of the Apes, H.G. Wells'
War of the Worlds, Zelazny's
Jack of Shadows, Cory Doctorow's work, Fritz Leiber's work, LeGuin's
The Lathe of Heaven, John Varley's work, etc. For younger readers, notably missing are Madeleine L'Engle's
A Wrinkle in Time, Eleanor Cameron's
The Wonderful Flight to the Mushroom Planet, Alexander Key's
The Forgotten Door, and a book which I have only a vague memory of involving encoded messages in seashells, chess, and unicorns (sorry, no author, title, or further details come to mind).
(Via
Pharyngula,
Respectful Insolence,
Evolving Thoughts,
A Blog Around the Clock, etc.)
UPDATE: And
Stranger Fruit,
Good Math, Bad Math, and
Afarensis...
Looks like Mark Chu-Carroll at Good Math, Bad Math has gone to the most trouble of annotating his list, as well as having read more of these books than anyone else.